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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 2
1976 1
1977 3
1979 1
1980 1
1982 2
1983 3
1985 1
1986 1
1987 2
1988 1
1989 3
1990 2
1991 5
1992 2
1993 3
1994 38
1995 147
1996 184
1997 241
1998 264
1999 306
2000 313
2001 335
2002 376
2003 385
2004 337
2005 355
2006 361
2007 377
2008 375
2009 325
2010 368
2011 347
2012 325
2013 317
2014 306
2015 321
2016 295
2017 255
2018 251
2019 238
2020 247
2021 233
2022 214
2023 206
2024 88

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8,051 results

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Page 1
Therapeutic Strategies for Targeting CDKN2A Loss in Melanoma.
Kreuger IZM, Slieker RC, van Groningen T, van Doorn R. Kreuger IZM, et al. J Invest Dermatol. 2023 Jan;143(1):18-25.e1. doi: 10.1016/j.jid.2022.07.016. Epub 2022 Sep 16. J Invest Dermatol. 2023. PMID: 36123181 Free article. Review.
Loss of the tumor suppressor gene CDKN2A, encoding p16 and p14, is a frequent event driving melanoma progression. Therefore, therapeutic strategies aimed at CDKN2A loss hold great potential to improve melanoma treatment. Pharmacological inhibition of the p16 targets …
Loss of the tumor suppressor gene CDKN2A, encoding p16 and p14, is a frequent event driving melanoma progression. Therefore, therapeu …
p16.
Serra S, Chetty R. Serra S, et al. J Clin Pathol. 2018 Oct;71(10):853-858. doi: 10.1136/jclinpath-2018-205216. Epub 2018 Aug 3. J Clin Pathol. 2018. PMID: 30076191 Review.
The p16 gene belongs to INK4 family of genes and is made up of four members: p16 (INK4A) , p15 (INK4B) , p18 (INK4C) and p19 (INK4D) , all of which share biological properties, namely, inhibition of cell growth and tumour suppression. ...Another use for p1 …
The p16 gene belongs to INK4 family of genes and is made up of four members: p16 (INK4A) , p15 (INK4B) , p18 (INK4C) an …
Role of the p16 tumor suppressor gene in cancer.
Liggett WH Jr, Sidransky D. Liggett WH Jr, et al. J Clin Oncol. 1998 Mar;16(3):1197-206. doi: 10.1200/JCO.1998.16.3.1197. J Clin Oncol. 1998. PMID: 9508208 Review.
The frequent mutations and deletions of p16 in human cancer cell lines first suggested an important role for p16 in carcinogenesis. ...This effect blocks the transcription of important cell-cycle regulatory proteins and results in cell-cycle arrest. Although p16 …
The frequent mutations and deletions of p16 in human cancer cell lines first suggested an important role for p16 in carcinogen …
p16(MTS-1/CDKN2/INK4a) in cancer progression.
Rocco JW, Sidransky D. Rocco JW, et al. Exp Cell Res. 2001 Mar 10;264(1):42-55. doi: 10.1006/excr.2000.5149. Exp Cell Res. 2001. PMID: 11237522 Review.
Since its discovery as an inhibitor of cyclin-dependent kinases 4 and 6, the tumor suppressor p16 has continued to gain widespread importance in cancer. The high frequency of deletions of p16 in tumor cell lines first suggested an important role for p16 in ca …
Since its discovery as an inhibitor of cyclin-dependent kinases 4 and 6, the tumor suppressor p16 has continued to gain widespread im …
Genes involved in senescence and immortalization.
Lundberg AS, Hahn WC, Gupta P, Weinberg RA. Lundberg AS, et al. Curr Opin Cell Biol. 2000 Dec;12(6):705-9. doi: 10.1016/s0955-0674(00)00155-1. Curr Opin Cell Biol. 2000. PMID: 11063935 Review.
The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence are being further elucidated. ...
The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence a …
Hereditary cutaneous melanoma.
Platz A, Ringborg U, Hansson J. Platz A, et al. Semin Cancer Biol. 2000 Aug;10(4):319-26. doi: 10.1006/scbi.2000.0149. Semin Cancer Biol. 2000. PMID: 10966854 Review.
Early Clinical Success of MTA-Cooperative PRMT5 Inhibitors for the Treatment of CDKN2A/MTAP-Deleted Cancers.
Mulvaney KM. Mulvaney KM. Cancer Discov. 2023 Nov 1;13(11):2310-2312. doi: 10.1158/2159-8290.CD-23-0951. Cancer Discov. 2023. PMID: 37909092
CDKN2A encodes the tumor suppressors p16 and p14ARF and is the most common homozygously deleted gene in all human cancers; tumors frequently codelete the nearby gene MTAP, creating a dependency on PRMT5. ...
CDKN2A encodes the tumor suppressors p16 and p14ARF and is the most common homozygously deleted gene in all human cancers; tumors fre …
Germline melanoma susceptibility and prognostic genes: a review of the literature.
Ward KA, Lazovich D, Hordinsky MK. Ward KA, et al. J Am Acad Dermatol. 2012 Nov;67(5):1055-67. doi: 10.1016/j.jaad.2012.02.042. Epub 2012 May 13. J Am Acad Dermatol. 2012. PMID: 22583682 Review.
The findings of these studies have indicated the presence of rare, high-penetrance alleles with large effects, such as CDKN2A and CDK4, more common, moderately penetrant genes like MC1R, and very common, low-penetrance polymorphisms with small effects that are related to p …
The findings of these studies have indicated the presence of rare, high-penetrance alleles with large effects, such as CDKN2A and CDK4, more …
The persistence of senescence.
Sharpless NE. Sharpless NE. Sci Aging Knowledge Environ. 2003 Aug 20;2003(33):PE24. doi: 10.1126/sageke.2003.33.pe24. Sci Aging Knowledge Environ. 2003. PMID: 12931012 Review.
8,051 results